Alone

• After losing his entire diagnostic team, House embarks on an elaborate, competition-style process to hire new fellows — pitting dozens of applicants against each other across multiple cases before ultimately selecting his new team members. • Foreman, having left House's team, attempts to forge his own path at another hospital but finds himself slipping into House-like behavior. He eventually returns to Princeton-Plainsboro and is placed in a supervisory role over the fellowship candidates. • The new team — including Thirteen, Kutner, Taub, and Amber ("Cutthroat Bitch") — is finalized after a season-long gauntlet of challenging cases, from a personality-mirroring patient to a CIA mystery case to a drug-using former punk rocker. • Wilson begins a new romantic relationship with Amber, House's former fellowship candidate, creating a contentious love triangle of sorts as House and Amber compete for Wilson's time and attention. • House's unorthodox methods remain on full display throughout the season, including diagnosing a researcher stranded at the South Pole remotely and kidnapping a soap opera actor he's convinced is seriously ill after spotting symptoms on TV. • The season builds to a devastating two-part finale: a bus crash leaves House with serious head trauma and amnesia, and he becomes consumed with identifying a fellow passenger who has a life-threatening condition — a mystery with deeply personal consequences for House and Wilson. • Wilson's growing concern for House's deteriorating health in the aftermath of the accident sets the stage for an emotional turning point in their friendship heading into the next season.